Detailed information of TA system TA029201

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1988537..1988844
• Replicon: chromosome
• Accession: NC_020564
• Organism: Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAI2T2_RS15675
• Protein ID: WP_011447039.1
• Coordinates: 1988668..1988844 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1988537..1988676 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAI2T2_RS09835	1984103..1984282	+	180	WP_000669791.1	hypothetical protein	-
SAI2T2_RS14880	1984593..1984853	+	261	WP_001791826.1	hypothetical protein	-
SAI2T2_RS09850	1984906..1985256	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAI2T2_RS09855	1985767..1986102	-	336	Protein_1854	SH3 domain-containing protein	-
SAI2T2_RS09860	1986753..1987244	-	492	WP_000920038.1	staphylokinase	-
SAI2T2_RS09865	1987435..1988190	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAI2T2_RS09870	1988202..1988456	-	255	WP_000611512.1	phage holin	-
SAI2T2_RS14885	1988508..1988615	+	108	WP_031762631.1	hypothetical protein	-
-	1988537..1988676	+	140	NuclAT_0	-	Antitoxin
-	1988537..1988676	+	140	NuclAT_0	-	Antitoxin
-	1988537..1988676	+	140	NuclAT_0	-	Antitoxin
-	1988537..1988676	+	140	NuclAT_0	-	Antitoxin
SAI2T2_RS15675	1988668..1988844	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAI2T2_RS09885	1988953..1989726	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAI2T2_RS09890	1990099..1990473	-	375	WP_000340977.1	hypothetical protein	-
SAI2T2_RS09895	1990529..1990816	-	288	WP_001262621.1	hypothetical protein	-
SAI2T2_RS14890	1990862..1991014	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / groEL	1984906..2024437	39531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29201 WP_011447039.1 NC_020564:c1988844-1988668 [Staphylococcus aureus subsp. aureus ST228]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29201 NC_020564:c1988844-1988668 [Staphylococcus aureus subsp. aureus ST228]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT29201 NC_020564:1988537-1988676 [Staphylococcus aureus subsp. aureus ST228]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin