Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1327..1957 Replicon plasmid 5
Accession NZ_LR890730
Organism Klebsiella pneumoniae isolate INF102-sc-2279897

Toxin (Protein)


Gene name higB Uniprot ID A0A3V9PY09
Locus tag JMX38_RS27500 Protein ID WP_001708474.1
Coordinates 1622..1957 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A704FLZ1
Locus tag JMX38_RS27495 Protein ID WP_001708475.1
Coordinates 1327..1617 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX38_RS27490 614..1267 - 654 WP_064163826.1 hypothetical protein -
JMX38_RS27495 1327..1617 - 291 WP_001708475.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JMX38_RS27500 1622..1957 - 336 WP_001708474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX38_RS27505 2160..2465 - 306 WP_181505416.1 hypothetical protein -
JMX38_RS27510 2567..2869 - 303 WP_060436025.1 hypothetical protein -
JMX38_RS27515 3182..3742 - 561 WP_060436024.1 hypothetical protein -
JMX38_RS27520 3760..4110 - 351 WP_060436023.1 hypothetical protein -
JMX38_RS27525 4107..4376 - 270 WP_060436022.1 hypothetical protein -
JMX38_RS27530 4390..4767 - 378 WP_181505417.1 hypothetical protein -
JMX38_RS27535 4893..6872 - 1980 WP_201553332.1 DUF87 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43065 43065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-104)

Antitoxin

Antitoxin MqsA/HigA-2

(21-94)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12615.30 Da        Isoelectric Point: 5.2407

>T291992 WP_001708474.1 NZ_LR890730:c1957-1622 [Klebsiella pneumoniae]
MEYYEFVETSVFTREMKTLLSDDEYKEFQTFLIENPEAGDLIVGTGGCRKVRWSRQGTGKSSGVRAIYYFYNPAGRLYML
IIYPKSEKDSLTAAEKNQLKAVVAGFKGEEG

Download         Length: 336 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10909.62 Da        Isoelectric Point: 10.0073

>AT291992 WP_001708475.1 NZ_LR890730:c1617-1327 [Klebsiella pneumoniae]
MRKELFDDLIASAKEAVEIHQGLREPARVTRFERPDVKAIRAKVHMKQDDFASLIGVSSSLVQSWEQGLRTPAGAALKLL
RVIERKPEFVQELREA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PY09

Antitoxin

Source ID Structure
AlphaFold DB A0A704FLZ1

References