Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2372498..2373187 Replicon chromosome
Accession NZ_LR890722
Organism Klebsiella pneumoniae isolate KSB1_1H

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag JMW72_RS11580 Protein ID WP_021469727.1
Coordinates 2372498..2372815 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMW72_RS11585 Protein ID WP_040147778.1
Coordinates 2372891..2373187 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW72_RS11550 2368200..2368709 + 510 WP_002906702.1 GNAT family N-acetyltransferase -
JMW72_RS11555 2368719..2369645 + 927 WP_032416224.1 amino acid ABC transporter permease -
JMW72_RS11560 2369629..2370408 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
JMW72_RS11565 2370447..2371298 + 852 WP_014343117.1 transporter substrate-binding domain-containing protein -
JMW72_RS11570 2371376..2371993 + 618 WP_040147782.1 glutathione S-transferase family protein -
JMW72_RS11575 2372064..2372291 + 228 WP_002906690.1 tautomerase PptA -
JMW72_RS11580 2372498..2372815 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW72_RS11585 2372891..2373187 + 297 WP_040147778.1 helix-turn-helix domain-containing protein Antitoxin
JMW72_RS11590 2373266..2373712 + 447 WP_004175959.1 hypothetical protein -
JMW72_RS11595 2373753..2375369 - 1617 WP_040147777.1 carbohydrate porin -
JMW72_RS11600 2375413..2376795 - 1383 WP_099743292.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T291969 WP_021469727.1 NZ_LR890722:2372498-2372815 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11032.88 Da        Isoelectric Point: 6.4721

>AT291969 WP_040147778.1 NZ_LR890722:2372891-2373187 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMPMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRQPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure

References