Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 72518..73052 Replicon plasmid pSymB
Accession NC_020560
Organism Sinorhizobium meliloti 2011

Toxin (Protein)


Gene name parE Uniprot ID Q92X99
Locus tag SM2011_RS06900 Protein ID WP_010974986.1
Coordinates 72756..73052 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag SM2011_RS06895 Protein ID WP_003527850.1
Coordinates 72518..72766 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM2011_RS06865 67708..68751 + 1044 WP_010974980.1 iron ABC transporter permease -
SM2011_RS06870 68748..69548 + 801 WP_010974981.1 ABC transporter ATP-binding protein -
SM2011_RS06875 69552..70331 + 780 WP_010974982.1 methyltransferase domain-containing protein -
SM2011_RS06880 70423..71619 + 1197 WP_010974983.1 IS256-like element ISRm5 family transposase -
SM2011_RS06885 71778..71903 - 126 Protein_61 IS481 family transposase -
SM2011_RS36105 72259..72414 + 156 WP_010974985.1 hypothetical protein -
SM2011_RS06895 72518..72766 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SM2011_RS06900 72756..73052 + 297 WP_010974986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SM2011_RS32475 73133..73393 - 261 Protein_65 helix-turn-helix domain containing protein -
SM2011_RS06905 73972..74370 + 399 WP_010974988.1 hypothetical protein -
SM2011_RS06910 74537..74722 + 186 WP_010974989.1 hypothetical protein -
SM2011_RS06915 74726..75172 - 447 WP_041170054.1 DNA-binding protein -
SM2011_RS06920 75462..75671 + 210 WP_003527838.1 dodecin family protein -
SM2011_RS06925 76205..77608 + 1404 WP_010974991.1 sodium:alanine symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1683348 1683348


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-91)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11473.15 Da        Isoelectric Point: 10.6593

>T29193 WP_010974986.1 NC_020560:72756-73052 [Sinorhizobium meliloti 2011]
MATERPFRLAPTAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAVGTKKGRNVDVRPGYLKYPAGAHIVYFRDRGD
RIDIIRILHGRVDAQRHL

Download         Length: 297 bp

>T29193 NC_020560:72756-73052 [Sinorhizobium meliloti 2011]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTACCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGTAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGGCCGGGTTATCTCAAATACCCGGCAGGAGCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGTGTGGACGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT29193 WP_003527850.1 NC_020560:72518-72766 [Sinorhizobium meliloti 2011]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT29193 NC_020560:72518-72766 [Sinorhizobium meliloti 2011]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92X99

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References