Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 49660..50387 | Replicon | plasmid 2 |
| Accession | NZ_LR890711 | ||
| Organism | Klebsiella pneumoniae isolate KSB2_9B | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Q9LNL2 |
| Locus tag | JMX55_RS25885 | Protein ID | WP_004118600.1 |
| Coordinates | 49660..49971 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | V0AHC4 |
| Locus tag | JMX55_RS25890 | Protein ID | WP_000990392.1 |
| Coordinates | 49968..50387 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JMX55_RS25865 | 46174..46893 | + | 720 | WP_001102107.1 | (Fe-S)-binding protein | - |
| JMX55_RS25870 | 46904..48331 | + | 1428 | WP_000023895.1 | iron-sulfur cluster-binding protein | - |
| JMX55_RS25875 | 48324..49019 | + | 696 | WP_004118595.1 | lactate utilization protein C | - |
| JMX55_RS25880 | 49069..49449 | - | 381 | Protein_44 | gluconate permease | - |
| JMX55_RS25885 | 49660..49971 | + | 312 | WP_004118600.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| JMX55_RS25890 | 49968..50387 | + | 420 | WP_000990392.1 | helix-turn-helix domain-containing protein | Antitoxin |
| JMX55_RS25895 | 50424..51626 | - | 1203 | WP_003031541.1 | hypothetical protein | - |
| JMX55_RS25900 | 51619..51948 | - | 330 | WP_004118613.1 | hypothetical protein | - |
| JMX55_RS25905 | 51945..52604 | - | 660 | WP_000078540.1 | hypothetical protein | - |
| JMX55_RS25910 | 53028..53621 | - | 594 | WP_044348674.1 | hypothetical protein | - |
| JMX55_RS25915 | 53937..54290 | + | 354 | WP_001114073.1 | As(III)-sensing metalloregulatory transcriptional repressor ArsR | - |
| JMX55_RS25920 | 54338..54700 | + | 363 | WP_020324593.1 | arsenite efflux transporter metallochaperone ArsD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..214404 | 214404 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12386.14 Da Isoelectric Point: 10.0935
>T291919 WP_004118600.1 NZ_LR890711:49660-49971 [Klebsiella pneumoniae]
MHIVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE
MHIVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15534.71 Da Isoelectric Point: 4.4702
>AT291919 WP_000990392.1 NZ_LR890711:49968-50387 [Klebsiella pneumoniae]
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LNL2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0AHC4 |