Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 5085734..5086331 Replicon chromosome
Accession NZ_LR890702
Organism Klebsiella pneumoniae isolate INF305-sc-2280094

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JMX64_RS25015 Protein ID WP_004142563.1
Coordinates 5085734..5086051 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMX64_RS25020 Protein ID WP_004142561.1
Coordinates 5086044..5086331 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX64_RS25000 5081434..5082861 - 1428 WP_009308097.1 MFS transporter -
JMX64_RS25005 5082970..5083836 + 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMX64_RS25010 5084506..5085549 + 1044 WP_040153598.1 DUF2157 domain-containing protein -
JMX64_RS25015 5085734..5086051 + 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX64_RS25020 5086044..5086331 + 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMX64_RS25025 5086596..5087234 - 639 WP_064277739.1 oxygen-insensitive NAD(P)H nitroreductase -
JMX64_RS25030 5087354..5087722 - 369 WP_040171587.1 MmcQ/YjbR family DNA-binding protein -
JMX64_RS25035 5087719..5088303 - 585 WP_094067239.1 TetR/AcrR family transcriptional regulator -
JMX64_RS25040 5088483..5089598 + 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JMX64_RS25045 5089629..5089970 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMX64_RS25050 5089988..5090236 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T291897 WP_004142563.1 NZ_LR890702:5085734-5086051 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT291897 WP_004142561.1 NZ_LR890702:5086044-5086331 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References