Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3436559..3437161 Replicon chromosome
Accession NZ_LR890693
Organism Escherichia coli isolate MSB1_4E-sc-2280348

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag JMW23_RS16900 Protein ID WP_000897302.1
Coordinates 3436559..3436870 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMW23_RS16905 Protein ID WP_000356397.1
Coordinates 3436871..3437161 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW23_RS16875 3432473..3433072 + 600 WP_001296610.1 glucose-1-phosphatase -
JMW23_RS16880 3433066..3433938 + 873 WP_000920762.1 virulence factor BrkB family protein -
JMW23_RS16885 3433935..3434372 + 438 WP_000560981.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW23_RS16890 3434417..3435358 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
JMW23_RS16895 3435422..3436330 - 909 WP_001385591.1 alpha/beta hydrolase -
JMW23_RS16900 3436559..3436870 + 312 WP_000897302.1 hypothetical protein Toxin
JMW23_RS16905 3436871..3437161 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
JMW23_RS16910 3437520..3437798 + 279 WP_001296612.1 hypothetical protein -
JMW23_RS16915 3438195..3438413 + 219 WP_001251293.1 ribbon-helix-helix domain-containing protein -
JMW23_RS16920 3438598..3439047 - 450 WP_032140890.1 hypothetical protein -
JMW23_RS16925 3439363..3440211 - 849 WP_001038650.1 hypothetical protein -
JMW23_RS16930 3440501..3440743 + 243 WP_001068514.1 ribbon-helix-helix domain-containing protein -
JMW23_RS16935 3440925..3441854 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T291866 WP_000897302.1 NZ_LR890693:3436559-3436870 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT291866 WP_000356397.1 NZ_LR890693:3436871-3437161 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References