291864

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2623857..2624656 Replicon chromosome
Accession NZ_LR890693
Organism Escherichia coli isolate MSB1_4E-sc-2280348

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag JMW23_RS12965 Protein ID WP_000347251.1
Coordinates 2624192..2624656 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag JMW23_RS12960 Protein ID WP_001296435.1
Coordinates 2623857..2624192 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW23_RS12945 2619642..2620412 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
JMW23_RS12950 2620428..2621762 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JMW23_RS12955 2622137..2623708 + 1572 WP_001273763.1 galactarate dehydratase -
JMW23_RS12960 2623857..2624192 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMW23_RS12965 2624192..2624656 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMW23_RS12970 2624711..2625520 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMW23_RS12975 2625769..2627049 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMW23_RS12980 2627072..2627545 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMW23_RS12985 2627556..2628335 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMW23_RS12990 2628325..2629203 + 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMW23_RS12995 2629221..2629655 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T291864 WP_000347251.1 NZ_LR890693:2624192-2624656 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT291864 WP_001296435.1 NZ_LR890693:2623857-2624192 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References