Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1303939..1304441 Replicon chromosome
Accession NZ_LR890693
Organism Escherichia coli isolate MSB1_4E-sc-2280348

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag JMW23_RS06875 Protein ID WP_000767819.1
Coordinates 1303939..1304193 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag JMW23_RS06880 Protein ID WP_001259253.1
Coordinates 1304190..1304441 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW23_RS06850 1299757..1300215 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
JMW23_RS06855 1300432..1301790 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
JMW23_RS06860 1301780..1301842 - 63 WP_010723108.1 membrane protein YoeI -
JMW23_RS06865 1302057..1302986 - 930 WP_000803366.1 LysR family transcriptional regulator -
JMW23_RS06870 1303032..1303856 - 825 WP_000754737.1 SDR family oxidoreductase -
JMW23_RS06875 1303939..1304193 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMW23_RS06880 1304190..1304441 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMW23_RS06885 1304724..1304774 + 51 WP_001364200.1 his operon leader peptide -
JMW23_RS06890 1304920..1305819 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
JMW23_RS06895 1305825..1307129 + 1305 WP_001296211.1 histidinol dehydrogenase -
JMW23_RS06900 1307126..1308196 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
JMW23_RS06905 1308196..1309263 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1299757..1300215 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T291860 WP_000767819.1 NZ_LR890693:c1304193-1303939 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT291860 WP_001259253.1 NZ_LR890693:c1304441-1304190 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References