Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2963469..2964117 Replicon
Accession NC_020559
Organism Mycobacterium tuberculosis str. Erdman = ATCC 35801

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag ERDMAN_RS13990 Protein ID WP_003899414.1
Coordinates 2963469..2963792 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag ERDMAN_RS13995 Protein ID WP_003899415.1
Coordinates 2963872..2964117 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ERDMAN_RS13960 2958792..2959790 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
ERDMAN_RS13965 2959804..2960268 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
ERDMAN_RS13970 2960256..2960507 + 252 WP_003908028.1 hypothetical protein -
ERDMAN_RS13975 2960678..2962117 - 1440 WP_003899411.1 phage major capsid protein -
ERDMAN_RS13980 2962125..2962658 - 534 WP_003899412.1 HK97 family phage prohead protease -
ERDMAN_RS21695 2962811..2963302 - 492 WP_003900541.1 phage terminase small subunit P27 family -
ERDMAN_RS13990 2963469..2963792 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
ERDMAN_RS13995 2963872..2964117 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
ERDMAN_RS14000 2964114..2965541 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
ERDMAN_RS14005 2965543..2965935 - 393 WP_003899417.1 DUF2742 domain-containing protein -
ERDMAN_RS14010 2965932..2966192 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
ERDMAN_RS14015 2966209..2966571 - 363 WP_003900543.1 hypothetical protein -
ERDMAN_RS14020 2966574..2967701 - 1128 WP_003899420.1 site-specific integrase -
ERDMAN_RS14025 2967846..2968073 - 228 WP_003899421.1 hypothetical protein -
ERDMAN_RS21700 2968070..2968459 - 390 WP_003899422.1 hypothetical protein -
ERDMAN_RS14030 2968365..2968637 + 273 WP_003900544.1 hypothetical protein -
ERDMAN_RS14035 2968736..2968969 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2958792..2967701 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T29180 WP_003899414.1 NC_020559:c2963792-2963469 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T29180 NC_020559:c2963792-2963469 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT29180 WP_003899415.1 NC_020559:c2964117-2963872 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT29180 NC_020559:c2964117-2963872 [Mycobacterium tuberculosis str. Erdman = ATCC 35801]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References