Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 362243..362889 Replicon chromosome
Accession NZ_LR890665
Organism Klebsiella pneumoniae isolate INF065-sc-2279980

Toxin (Protein)


Gene name higB Uniprot ID A0A6B2JGE6
Locus tag JMX32_RS01665 Protein ID WP_048299688.1
Coordinates 362243..362590 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag JMX32_RS01670 Protein ID WP_002920557.1
Coordinates 362590..362889 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX32_RS01655 358179..359612 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMX32_RS01660 359630..362077 + 2448 WP_021312822.1 glycogen phosphorylase -
JMX32_RS01665 362243..362590 + 348 WP_048299688.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX32_RS01670 362590..362889 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
JMX32_RS01675 362952..364460 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
JMX32_RS01680 364665..364994 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMX32_RS01685 365045..365875 + 831 WP_201531633.1 rhomboid family intramembrane serine protease GlpG -
JMX32_RS01690 365925..366683 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13562.56 Da        Isoelectric Point: 5.6749

>T291761 WP_048299688.1 NZ_LR890665:362243-362590 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRDLKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT291761 WP_002920557.1 NZ_LR890665:362590-362889 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B2JGE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References