Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4443241..4443893 Replicon chromosome
Accession NZ_LR890657
Organism Serratia marcescens isolate MSB1_9C-sc-2280320

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMX15_RS21350 Protein ID WP_038878669.1
Coordinates 4443241..4443585 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B4GZD7
Locus tag JMX15_RS21355 Protein ID WP_038878665.1
Coordinates 4443591..4443893 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX15_RS21335 4439397..4439582 - 186 WP_038878678.1 hypothetical protein -
JMX15_RS21340 4439583..4441841 - 2259 WP_038878674.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
JMX15_RS21345 4442062..4443081 + 1020 WP_038878671.1 HTH-type transcriptional regulator GalR -
JMX15_RS21350 4443241..4443585 + 345 WP_038878669.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX15_RS21355 4443591..4443893 + 303 WP_038878665.1 helix-turn-helix transcriptional regulator Antitoxin
JMX15_RS21360 4443921..4445183 - 1263 WP_038878662.1 diaminopimelate decarboxylase -
JMX15_RS21365 4445317..4446240 + 924 WP_038878659.1 LysR family transcriptional regulator -
JMX15_RS21370 4446268..4447176 - 909 WP_038878655.1 LysR family transcriptional regulator -
JMX15_RS21375 4447285..4448169 + 885 WP_201621402.1 MBL fold metallo-hydrolase -
JMX15_RS21380 4448238..4448885 + 648 WP_038878652.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13367.40 Da        Isoelectric Point: 10.6629

>T291754 WP_038878669.1 NZ_LR890657:4443241-4443585 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDQRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11111.04 Da        Isoelectric Point: 10.3986

>AT291754 WP_038878665.1 NZ_LR890657:4443591-4443893 [Serratia marcescens]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GZD7

References