Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4739132..4739734 Replicon chromosome
Accession NZ_LR890651
Organism Escherichia coli isolate MINF_2E-sc-2280463

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag JMW95_RS22940 Protein ID WP_000897305.1
Coordinates 4739423..4739734 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMW95_RS22935 Protein ID WP_000356397.1
Coordinates 4739132..4739422 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW95_RS22910 4735058..4735960 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
JMW95_RS22915 4735957..4736592 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
JMW95_RS22920 4736589..4737518 + 930 WP_001749031.1 formate dehydrogenase accessory protein FdhE -
JMW95_RS22925 4737848..4738090 - 243 WP_001086388.1 hypothetical protein -
JMW95_RS22930 4738309..4738527 - 219 WP_001295676.1 ribbon-helix-helix domain-containing protein -
JMW95_RS22935 4739132..4739422 - 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
JMW95_RS22940 4739423..4739734 - 312 WP_000897305.1 hypothetical protein Toxin
JMW95_RS22945 4739963..4740871 + 909 WP_001162704.1 alpha/beta hydrolase -
JMW95_RS22950 4740935..4741876 - 942 WP_001343389.1 fatty acid biosynthesis protein FabY -
JMW95_RS22955 4741921..4742358 - 438 WP_000560983.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW95_RS22960 4742355..4743227 - 873 WP_000920762.1 virulence factor BrkB family protein -
JMW95_RS22965 4743221..4743820 - 600 WP_001295269.1 glucose-1-phosphatase -
JMW95_RS22970 4743919..4744704 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T291722 WP_000897305.1 NZ_LR890651:c4739734-4739423 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT291722 WP_000356397.1 NZ_LR890651:c4739422-4739132 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References