Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3901615..3902156 Replicon chromosome
Accession NZ_LR890651
Organism Escherichia coli isolate MINF_2E-sc-2280463

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag JMW95_RS19125 Protein ID WP_000615982.1
Coordinates 3901878..3902156 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag JMW95_RS19120 Protein ID WP_000729704.1
Coordinates 3901615..3901875 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW95_RS19095 3897398..3898183 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
JMW95_RS19100 3898155..3899867 + 1713 Protein_3742 flagellar biosynthesis protein FlhA -
JMW95_RS19105 3899972..3900250 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
JMW95_RS19110 3900243..3900599 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
JMW95_RS19115 3900656..3901429 - 774 WP_000543899.1 C40 family peptidase -
JMW95_RS19120 3901615..3901875 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JMW95_RS19125 3901878..3902156 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JMW95_RS19130 3902312..3903052 + 741 WP_001225679.1 murein L,D-transpeptidase -
JMW95_RS19135 3903023..3903790 - 768 WP_000333380.1 class II glutamine amidotransferase -
JMW95_RS19140 3903996..3904574 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T291720 WP_000615982.1 NZ_LR890651:3901878-3902156 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT291720 WP_000729704.1 NZ_LR890651:3901615-3901875 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References