Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1908757..1909259 Replicon chromosome
Accession NZ_LR890651
Organism Escherichia coli isolate MINF_2E-sc-2280463

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMW95_RS09360 Protein ID WP_000767829.1
Coordinates 1909005..1909259 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMW95_RS09355 Protein ID WP_001259255.1
Coordinates 1908757..1909008 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW95_RS09330 1903935..1905002 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMW95_RS09335 1905002..1906072 - 1071 WP_000108980.1 histidinol-phosphate transaminase -
JMW95_RS09340 1906069..1907373 - 1305 WP_001298841.1 histidinol dehydrogenase -
JMW95_RS09345 1907379..1908278 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JMW95_RS09350 1908424..1908474 - 51 WP_001368802.1 his operon leader peptide -
JMW95_RS09355 1908757..1909008 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMW95_RS09360 1909005..1909259 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMW95_RS09365 1909342..1910166 + 825 WP_000754737.1 SDR family oxidoreductase -
JMW95_RS09370 1910212..1911141 + 930 WP_000803351.1 LysR family transcriptional regulator -
JMW95_RS09375 1911356..1911418 + 63 WP_010723108.1 membrane protein YoeI -
JMW95_RS09380 1911408..1912766 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMW95_RS09385 1912945..1914003 + 1059 WP_000492346.1 transport protein YeeE -
JMW95_RS09390 1914017..1914244 + 228 WP_000985280.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T291712 WP_000767829.1 NZ_LR890651:1909005-1909259 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT291712 WP_001259255.1 NZ_LR890651:1908757-1909008 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References