Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1318..1948 Replicon plasmid 3
Accession NZ_LR890645
Organism Klebsiella pneumoniae isolate INF346-sc-2280166

Toxin (Protein)


Gene name higB Uniprot ID A0A3V9PY09
Locus tag JMW14_RS25710 Protein ID WP_001708474.1
Coordinates 1613..1948 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A704FLZ1
Locus tag JMW14_RS25705 Protein ID WP_001708475.1
Coordinates 1318..1608 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW14_RS25700 605..1258 - 654 WP_001708476.1 hypothetical protein -
JMW14_RS25705 1318..1608 - 291 WP_001708475.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JMW14_RS25710 1613..1948 - 336 WP_001708474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW14_RS25715 2153..2821 - 669 WP_044296050.1 hypothetical protein -
JMW14_RS25720 2871..3197 - 327 WP_044296048.1 hypothetical protein -
JMW14_RS25725 3510..4070 - 561 WP_052957587.1 hypothetical protein -
JMW14_RS25730 4088..4438 - 351 WP_142762106.1 hypothetical protein -
JMW14_RS25735 4473..4808 - 336 WP_094340933.1 hypothetical protein -
JMW14_RS25740 4805..5074 - 270 WP_024172976.1 hypothetical protein -
JMW14_RS25745 5088..5465 - 378 WP_069346704.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..44191 44191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-104)

Antitoxin

Antitoxin MqsA/HigA-2

(21-94)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12615.30 Da        Isoelectric Point: 5.2407

>T291689 WP_001708474.1 NZ_LR890645:c1948-1613 [Klebsiella pneumoniae]
MEYYEFVETSVFTREMKTLLSDDEYKEFQTFLIENPEAGDLIVGTGGCRKVRWSRQGTGKSSGVRAIYYFYNPAGRLYML
IIYPKSEKDSLTAAEKNQLKAVVAGFKGEEG

Download         Length: 336 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10909.62 Da        Isoelectric Point: 10.0073

>AT291689 WP_001708475.1 NZ_LR890645:c1608-1318 [Klebsiella pneumoniae]
MRKELFDDLIASAKEAVEIHQGLREPARVTRFERPDVKAIRAKVHMKQDDFASLIGVSSSLVQSWEQGLRTPAGAALKLL
RVIERKPEFVQELREA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PY09

Antitoxin

Source ID Structure
AlphaFold DB A0A704FLZ1

References