291667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4531784..4532559 Replicon chromosome
Accession NZ_LR890640
Organism Klebsiella pneumoniae isolate INF344-sc-2280162

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag JMW76_RS22045 Protein ID WP_021314147.1
Coordinates 4532074..4532559 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMW76_RS22040 Protein ID WP_004150912.1
Coordinates 4531784..4532077 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW76_RS22020 4526992..4527594 - 603 WP_004174410.1 short chain dehydrogenase -
JMW76_RS22025 4527692..4528603 + 912 WP_201524319.1 LysR family transcriptional regulator -
JMW76_RS22030 4528604..4529752 - 1149 WP_020316731.1 PLP-dependent aspartate aminotransferase family protein -
JMW76_RS22035 4529763..4531139 - 1377 WP_004174417.1 pyridoxal-phosphate dependent enzyme -
JMW76_RS22040 4531784..4532077 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMW76_RS22045 4532074..4532559 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
JMW76_RS22050 4533263..4533856 + 594 WP_004188553.1 hypothetical protein -
JMW76_RS22055 4533953..4534169 + 217 Protein_4302 transposase -
JMW76_RS22065 4534684..4535397 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4533953..4534105 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T291667 WP_021314147.1 NZ_LR890640:4532074-4532559 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291667 WP_004150912.1 NZ_LR890640:4531784-4532077 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References