Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 5082896..5083493 Replicon chromosome
Accession NZ_LR890632
Organism Klebsiella pneumoniae isolate INF299-sc-2280084

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JMX65_RS25000 Protein ID WP_004142563.1
Coordinates 5082896..5083213 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMX65_RS25005 Protein ID WP_004142561.1
Coordinates 5083206..5083493 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX65_RS24985 5078596..5080023 - 1428 WP_009308097.1 MFS transporter -
JMX65_RS24990 5080132..5080998 + 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMX65_RS24995 5081668..5082711 + 1044 WP_040153598.1 DUF2157 domain-containing protein -
JMX65_RS25000 5082896..5083213 + 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX65_RS25005 5083206..5083493 + 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMX65_RS25010 5083758..5084396 - 639 WP_064277739.1 oxygen-insensitive NAD(P)H nitroreductase -
JMX65_RS25015 5084516..5084884 - 369 WP_040171587.1 MmcQ/YjbR family DNA-binding protein -
JMX65_RS25020 5084881..5085465 - 585 WP_094067239.1 TetR/AcrR family transcriptional regulator -
JMX65_RS25025 5085645..5086760 + 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JMX65_RS25030 5086791..5087132 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMX65_RS25035 5087150..5087398 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T291646 WP_004142563.1 NZ_LR890632:5082896-5083213 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT291646 WP_004142561.1 NZ_LR890632:5083206-5083493 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References