Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 730393..731168 Replicon chromosome
Accession NZ_LR890624
Organism Klebsiella pneumoniae isolate INF242-sc-2280140

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag JMX20_RS03640 Protein ID WP_009308645.1
Coordinates 730683..731168 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMX20_RS03635 Protein ID WP_004150912.1
Coordinates 730393..730686 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX20_RS03615 725603..726205 - 603 WP_004174410.1 short chain dehydrogenase -
JMX20_RS03620 726303..727214 + 912 WP_015958983.1 LysR family transcriptional regulator -
JMX20_RS03625 727215..728363 - 1149 WP_065805152.1 PLP-dependent aspartate aminotransferase family protein -
JMX20_RS03630 728374..729750 - 1377 WP_004217775.1 cystathionine beta-synthase -
JMX20_RS03635 730393..730686 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMX20_RS03640 730683..731168 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
JMX20_RS03645 731872..732464 + 593 Protein_715 hypothetical protein -
JMX20_RS03650 732561..732777 + 217 Protein_716 transposase -
JMX20_RS03660 733455..734168 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 732561..732713 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T291618 WP_009308645.1 NZ_LR890624:730683-731168 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291618 WP_004150912.1 NZ_LR890624:730393-730686 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References