Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5238195..5238790 Replicon chromosome
Accession NZ_LR890619
Organism Pseudomonas aeruginosa isolate MINF_7A-sc-2280434

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag JMW66_RS24260 Protein ID WP_003113526.1
Coordinates 5238512..5238790 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMW66_RS24255 Protein ID WP_003113527.1
Coordinates 5238195..5238500 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW66_RS24215 5233307..5233597 - 291 WP_023088865.1 DUF5447 family protein -
JMW66_RS24220 5233601..5233783 - 183 WP_124129801.1 hypothetical protein -
JMW66_RS24225 5233773..5234045 - 273 WP_004352675.1 hypothetical protein -
JMW66_RS24230 5234155..5234421 + 267 WP_023088595.1 hypothetical protein -
JMW66_RS24235 5234477..5234812 + 336 WP_031756230.1 hypothetical protein -
JMW66_RS24240 5234867..5236564 - 1698 WP_074222664.1 DUF2326 domain-containing protein -
JMW66_RS24245 5236771..5237319 - 549 WP_031756228.1 hypothetical protein -
JMW66_RS24250 5237327..5237581 - 255 WP_071575691.1 hypothetical protein -
JMW66_RS24255 5238195..5238500 - 306 WP_003113527.1 HigA family addiction module antidote protein Antitoxin
JMW66_RS24260 5238512..5238790 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW66_RS24265 5239119..5241347 + 2229 WP_023086667.1 TonB-dependent receptor -
JMW66_RS24270 5241417..5242064 - 648 WP_096264608.1 carbonate dehydratase -
JMW66_RS24275 5242126..5243364 - 1239 WP_201522542.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T291598 WP_003113526.1 NZ_LR890619:c5238790-5238512 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT291598 WP_003113527.1 NZ_LR890619:c5238500-5238195 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References