Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3792738..3793279 Replicon chromosome
Accession NZ_LR890606
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag JMW69_RS18305 Protein ID WP_000615983.1
Coordinates 3793001..3793279 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag JMW69_RS18300 Protein ID WP_000729703.1
Coordinates 3792738..3792998 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS18280 3788413..3789198 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
JMW69_RS18285 3789170..3790882 + 1713 Protein_3577 flagellar biosynthesis protein FlhA -
JMW69_RS18290 3791106..3791603 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
JMW69_RS18295 3791779..3792528 - 750 WP_000056849.1 C40 family peptidase -
JMW69_RS18300 3792738..3792998 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JMW69_RS18305 3793001..3793279 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JMW69_RS18310 3793435..3794175 + 741 WP_001225679.1 murein L,D-transpeptidase -
JMW69_RS18315 3794146..3794913 - 768 WP_000333380.1 class II glutamine amidotransferase -
JMW69_RS18320 3795119..3795697 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T291559 WP_000615983.1 NZ_LR890606:3793001-3793279 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT291559 WP_000729703.1 NZ_LR890606:3792738-3792998 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References