Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1855246..1855748 Replicon chromosome
Accession NZ_LR890606
Organism Escherichia coli isolate MINF_8D-sc-2280460

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMW69_RS08750 Protein ID WP_000767829.1
Coordinates 1855494..1855748 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMW69_RS08745 Protein ID WP_001259255.1
Coordinates 1855246..1855497 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW69_RS08720 1850424..1851491 - 1068 WP_000080141.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMW69_RS08725 1851491..1852561 - 1071 WP_001518029.1 histidinol-phosphate transaminase -
JMW69_RS08730 1852558..1853862 - 1305 WP_001367667.1 histidinol dehydrogenase -
JMW69_RS08735 1853868..1854767 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
JMW69_RS08740 1854913..1854963 - 51 WP_001364200.1 his operon leader peptide -
JMW69_RS08745 1855246..1855497 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMW69_RS08750 1855494..1855748 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMW69_RS08755 1855831..1856655 + 825 WP_000754737.1 SDR family oxidoreductase -
JMW69_RS08760 1856701..1857630 + 930 WP_000803351.1 LysR family transcriptional regulator -
JMW69_RS08765 1857845..1857907 + 63 WP_010723108.1 membrane protein YoeI -
JMW69_RS08770 1857897..1859255 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMW69_RS08775 1859434..1860492 + 1059 WP_000492333.1 transport protein YeeE -
JMW69_RS08780 1860506..1860733 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T291550 WP_000767829.1 NZ_LR890606:1855494-1855748 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT291550 WP_001259255.1 NZ_LR890606:1855246-1855497 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References