Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3723393..3723934 Replicon chromosome
Accession NZ_LR890603
Organism Escherichia coli isolate MSB1_8G-sc-2280388

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag JMW40_RS17805 Protein ID WP_000615983.1
Coordinates 3723656..3723934 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag JMW40_RS17800 Protein ID WP_000729703.1
Coordinates 3723393..3723653 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW40_RS17780 3719068..3719853 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
JMW40_RS17785 3719825..3721537 + 1713 Protein_3476 flagellar biosynthesis protein FlhA -
JMW40_RS17790 3721761..3722258 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
JMW40_RS17795 3722434..3723183 - 750 WP_000056849.1 C40 family peptidase -
JMW40_RS17800 3723393..3723653 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JMW40_RS17805 3723656..3723934 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JMW40_RS17810 3724090..3724830 + 741 WP_001225679.1 murein L,D-transpeptidase -
JMW40_RS17815 3724801..3725568 - 768 WP_000333380.1 class II glutamine amidotransferase -
JMW40_RS17820 3725774..3726352 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T291527 WP_000615983.1 NZ_LR890603:3723656-3723934 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT291527 WP_000729703.1 NZ_LR890603:3723393-3723653 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References