Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 721378..722153 Replicon chromosome
Accession NZ_LR890600
Organism Klebsiella pneumoniae isolate INF122-sc-2279936

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag JMW81_RS03565 Protein ID WP_021314147.1
Coordinates 721668..722153 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMW81_RS03560 Protein ID WP_004150912.1
Coordinates 721378..721671 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW81_RS03540 716586..717188 - 603 WP_021440720.1 short chain dehydrogenase -
JMW81_RS03545 717286..718197 + 912 WP_004188550.1 LysR family transcriptional regulator -
JMW81_RS03550 718198..719346 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
JMW81_RS03555 719357..720733 - 1377 WP_074194669.1 cystathionine beta-synthase -
JMW81_RS03560 721378..721671 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMW81_RS03565 721668..722153 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
JMW81_RS03570 722857..723450 + 594 WP_004188553.1 hypothetical protein -
JMW81_RS03575 723547..723763 + 217 Protein_701 transposase -
JMW81_RS03580 724538..725422 + 885 WP_013095145.1 ParA family protein -
JMW81_RS03585 725415..726779 + 1365 WP_044158999.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 723547..723699 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T291496 WP_021314147.1 NZ_LR890600:721668-722153 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291496 WP_004150912.1 NZ_LR890600:721378-721671 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References