Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 331694..332280 Replicon chromosome
Accession NZ_LR890583
Organism Klebsiella pneumoniae isolate INF145-sc-2279981

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag JMW91_RS01540 Protein ID WP_002920800.1
Coordinates 331912..332280 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag JMW91_RS01535 Protein ID WP_004174006.1
Coordinates 331694..331915 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW91_RS01515 327851..328777 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JMW91_RS01520 328774..330051 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
JMW91_RS01525 330048..330815 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JMW91_RS01530 330817..331530 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
JMW91_RS01535 331694..331915 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMW91_RS01540 331912..332280 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JMW91_RS01545 332553..333869 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
JMW91_RS01550 333976..334863 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
JMW91_RS01555 334860..335705 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
JMW91_RS01560 335707..336777 + 1071 WP_004889423.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 328774..337514 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T291464 WP_002920800.1 NZ_LR890583:331912-332280 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT291464 WP_004174006.1 NZ_LR890583:331694-331915 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References