Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3800498..3801095 Replicon chromosome
Accession NZ_LR890562
Organism Klebsiella pneumoniae isolate INF247-sc-2280148

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JMW77_RS18775 Protein ID WP_004142563.1
Coordinates 3800778..3801095 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMW77_RS18770 Protein ID WP_004142561.1
Coordinates 3800498..3800785 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW77_RS18740 3796578..3796826 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JMW77_RS18745 3796844..3797185 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMW77_RS18750 3797216..3798331 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JMW77_RS18755 3798511..3799092 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
JMW77_RS18760 3799092..3799460 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JMW77_RS18765 3799580..3800233 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JMW77_RS18770 3800498..3800785 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMW77_RS18775 3800778..3801095 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW77_RS18780 3801280..3802323 - 1044 WP_048336957.1 DUF2157 domain-containing protein -
JMW77_RS18785 3802989..3803855 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMW77_RS18790 3803964..3805391 + 1428 WP_023300814.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T291408 WP_004142563.1 NZ_LR890562:c3801095-3800778 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT291408 WP_004142561.1 NZ_LR890562:c3800785-3800498 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References