291342

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3888508..3889105 Replicon chromosome
Accession NZ_LR890542
Organism Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag JMX54_RS19060 Protein ID WP_004142563.1
Coordinates 3888788..3889105 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMX54_RS19055 Protein ID WP_004142561.1
Coordinates 3888508..3888795 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX54_RS19025 3884588..3884836 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JMX54_RS19030 3884854..3885195 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMX54_RS19035 3885226..3886341 - 1116 WP_020316605.1 MBL fold metallo-hydrolase -
JMX54_RS19040 3886521..3887102 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
JMX54_RS19045 3887102..3887470 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
JMX54_RS19050 3887590..3888243 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JMX54_RS19055 3888508..3888795 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMX54_RS19060 3888788..3889105 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX54_RS19065 3889290..3890333 - 1044 WP_048988693.1 DUF2157 domain-containing protein -
JMX54_RS19070 3890999..3891865 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMX54_RS19075 3891974..3893401 + 1428 WP_009308097.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T291342 WP_004142563.1 NZ_LR890542:c3889105-3888788 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT291342 WP_004142561.1 NZ_LR890542:c3888795-3888508 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References