291317

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 4028374..4029068 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name yafO Uniprot ID Q0T7Q5
Locus tag JMX06_RS19415 Protein ID WP_001263491.1
Coordinates 4028374..4028772 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID L4JHF0
Locus tag JMX06_RS19420 Protein ID WP_000554755.1
Coordinates 4028775..4029068 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS19385 4023636..4025093 + 1458 WP_022645227.1 cytosol nonspecific dipeptidase -
JMX06_RS19390 4025102..4025383 + 282 WP_022645226.1 hypothetical protein -
JMX06_RS19395 4025400..4025909 - 510 WP_001361775.1 hydrolase -
JMX06_RS19400 4025971..4026585 - 615 WP_022645225.1 peptide chain release factor H -
JMX06_RS19405 4026582..4027721 - 1140 WP_022645224.1 RNA ligase RtcB family protein -
JMX06_RS19410 4027912..4028364 - 453 WP_023909048.1 GNAT family N-acetyltransferase -
JMX06_RS19415 4028374..4028772 - 399 WP_001263491.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
JMX06_RS19420 4028775..4029068 - 294 WP_000554755.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
JMX06_RS19425 4029120..4030175 - 1056 WP_022645222.1 DNA polymerase IV -
JMX06_RS19430 4030246..4031031 - 786 WP_072224360.1 putative lateral flagellar export/assembly protein LafU -
JMX06_RS19435 4031003..4032715 + 1713 Protein_3810 flagellar biosynthesis protein FlhA -
JMX06_RS19440 4032813..4033586 - 774 WP_022645219.1 C40 family peptidase -
JMX06_RS19445 4033772..4034032 + 261 WP_000729708.1 type II toxin-antitoxin system antitoxin DinJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15457.86 Da        Isoelectric Point: 8.0949

>T291317 WP_001263491.1 NZ_LR890536:c4028772-4028374 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11235.78 Da        Isoelectric Point: 5.2170

>AT291317 WP_000554755.1 NZ_LR890536:c4029068-4028775 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKLVKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TPK7

Antitoxin

Source ID Structure
AlphaFold DB A0A829G9H5

References