Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2046080..2046582 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMX06_RS09670 Protein ID WP_000767829.1
Coordinates 2046328..2046582 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMX06_RS09665 Protein ID WP_001259255.1
Coordinates 2046080..2046331 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS09640 2041258..2042325 - 1068 WP_000080136.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMX06_RS09645 2042325..2043395 - 1071 WP_000108937.1 histidinol-phosphate transaminase -
JMX06_RS09650 2043392..2044696 - 1305 WP_021523144.1 histidinol dehydrogenase -
JMX06_RS09655 2044702..2045601 - 900 WP_021523143.1 ATP phosphoribosyltransferase -
JMX06_RS09660 2045747..2045797 - 51 WP_001364200.1 his operon leader peptide -
JMX06_RS09665 2046080..2046331 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMX06_RS09670 2046328..2046582 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMX06_RS09675 2046665..2047489 + 825 WP_000754758.1 SDR family oxidoreductase -
JMX06_RS09680 2047535..2048464 + 930 WP_023154044.1 LysR family transcriptional regulator -
JMX06_RS09685 2048679..2048741 + 63 WP_010723108.1 membrane protein YoeI -
JMX06_RS09690 2048731..2050089 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMX06_RS09695 2050268..2051326 + 1059 WP_000492324.1 transport protein YeeE -
JMX06_RS09700 2051340..2051567 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T291307 WP_000767829.1 NZ_LR890536:2046328-2046582 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT291307 WP_001259255.1 NZ_LR890536:2046080-2046331 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References