Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 693468..694267 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag JMX06_RS03325 Protein ID WP_000347273.1
Coordinates 693468..693932 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag JMX06_RS03330 Protein ID WP_001308975.1
Coordinates 693932..694267 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS03295 688469..688903 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
JMX06_RS03300 688921..689799 - 879 WP_001298314.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMX06_RS03305 689789..690568 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMX06_RS03310 690579..691052 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMX06_RS03315 691075..692355 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMX06_RS03320 692604..693413 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMX06_RS03325 693468..693932 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMX06_RS03330 693932..694267 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMX06_RS03335 694416..695987 - 1572 WP_023908830.1 galactarate dehydratase -
JMX06_RS03340 696362..697696 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JMX06_RS03345 697712..698482 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T291303 WP_000347273.1 NZ_LR890536:c693932-693468 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT291303 WP_001308975.1 NZ_LR890536:c694267-693932 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References