Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3717026..3717623 Replicon chromosome
Accession NZ_LR890527
Organism Klebsiella pneumoniae isolate INF361-sc-2280198

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag JMW73_RS18235 Protein ID WP_004893639.1
Coordinates 3717306..3717623 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag JMW73_RS18230 Protein ID WP_004142561.1
Coordinates 3717026..3717313 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW73_RS18200 3713106..3713354 + 249 WP_002893037.1 DUF1158 domain-containing protein -
JMW73_RS18205 3713372..3713713 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
JMW73_RS18210 3713744..3714859 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
JMW73_RS18215 3715039..3715623 + 585 WP_002893026.1 TetR/AcrR family transcriptional regulator -
JMW73_RS18220 3715620..3715988 + 369 WP_002893024.1 MmcQ/YjbR family DNA-binding protein -
JMW73_RS18225 3716108..3716761 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JMW73_RS18230 3717026..3717313 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
JMW73_RS18235 3717306..3717623 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW73_RS18240 3717808..3718851 - 1044 WP_021314069.1 DUF2157 domain-containing protein -
JMW73_RS18245 3719517..3720383 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
JMW73_RS18250 3720492..3721919 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T291290 WP_004893639.1 NZ_LR890527:c3717623-3717306 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT291290 WP_004142561.1 NZ_LR890527:c3717313-3717026 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References