Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2281761..2282418 Replicon chromosome
Accession NZ_LR890524
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ISX57_RS27775 Protein ID WP_194132115.1
Coordinates 2282086..2282418 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ISX57_RS27770 Protein ID WP_194131647.1
Coordinates 2281761..2282093 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS27745 2279971..2280186 + 216 WP_194132114.1 type I toxin-antitoxin system SymE family toxin -
ISX57_RS27750 2280186..2280506 + 321 WP_006494466.1 XRE family transcriptional regulator -
ISX57_RS27755 2280605..2280829 + 225 WP_194131644.1 hypothetical protein -
ISX57_RS27760 2280819..2281313 + 495 WP_194131645.1 DUF2384 domain-containing protein -
ISX57_RS27765 2281341..2281661 + 321 WP_194131646.1 helix-turn-helix domain-containing protein -
ISX57_RS27770 2281761..2282093 - 333 WP_194131647.1 helix-turn-helix domain-containing protein Antitoxin
ISX57_RS27775 2282086..2282418 - 333 WP_194132115.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISX57_RS27780 2282798..2283640 - 843 WP_194131648.1 peptidyl-prolyl cis-trans isomerase -
ISX57_RS27785 2284175..2284984 - 810 WP_194131649.1 glycosyltransferase family 25 protein -
ISX57_RS27790 2284978..2285292 - 315 WP_006494471.1 hypothetical protein -
ISX57_RS27795 2285639..2287213 + 1575 WP_194131650.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12969.09 Da        Isoelectric Point: 9.9906

>T291279 WP_194132115.1 NZ_LR890524:c2282418-2282086 [Burkholderia cepacia]
MKNWTILYYDERVKRDVFALPKGILASYLRLIETMEEHGADLRMPHSRAMGAGLFELRPRGREGIGRVFYCVQVRYELVI
LHSFVKKTQETPEDELRIARRRMKEVQSNG

Download         Length: 333 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12053.67 Da        Isoelectric Point: 8.9657

>AT291279 WP_194131647.1 NZ_LR890524:c2282093-2281761 [Burkholderia cepacia]
MAKARPARANEDRYVPVRHTAEDTARLLSDPVIKAEYDALEEEFTALRALLDARKEAGLTQAQVAERMGTTTSAVSRLEA
SLSSEKHSPSFSTLRRYAAACGKKLIISFA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References