Detailed information of TA system TA291270

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 69559..69812
• Replicon: plasmid 5
• Accession: NZ_LR890519
• Organism: Klebsiella pneumoniae isolate INF281-sc-2280206

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: G9G1E3
• Locus tag: JMX78_RS29660
• Protein ID: WP_001312851.1
• Coordinates: 69663..69812 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	69559..69618 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX78_RS29625	65335..66195	+	861	WP_000704523.1	alpha/beta hydrolase	-
JMX78_RS29630	66298..66858	+	561	WP_000139321.1	fertility inhibition protein FinO	-
JMX78_RS29635	66987..67199	+	213	WP_001309245.1	ANR family transcriptional regulator	-
JMX78_RS29640	67444..67905	+	462	WP_001233838.1	thermonuclease family protein	-
JMX78_RS29645	67951..68160	+	210	WP_001298565.1	hemolysin expression modulator Hha	-
JMX78_RS29650	68198..68788	+	591	WP_033807967.1	DUF2726 domain-containing protein	-
JMX78_RS29655	68943..69416	+	474	WP_016240489.1	hypothetical protein	-
-	69559..69618	-	60	NuclAT_1	-	Antitoxin
-	69559..69618	-	60	NuclAT_1	-	Antitoxin
-	69559..69618	-	60	NuclAT_1	-	Antitoxin
-	69559..69618	-	60	NuclAT_1	-	Antitoxin
JMX78_RS29660	69663..69812	+	150	WP_001312851.1	type I toxin-antitoxin system Hok family toxin	Toxin
JMX78_RS29665	70097..70345	+	249	WP_000083839.1	replication regulatory protein RepA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	erm(B)	-	1..70656	70656

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T291270 WP_001312851.1 NZ_LR890519:69663-69812 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

Antitoxin

Nucleotide

• Length: 60 bp

>AT291270 NZ_LR890519:c69618-69559 [Klebsiella pneumoniae]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A829C8K5

Antitoxin