Detailed information of TA system TA291238

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 29147..29401
• Replicon: plasmid 2
• Accession: NZ_LR890509
• Organism: Escherichia coli isolate MSB1_9I-sc-2280417

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: JMW57_RS23085
• Protein ID: WP_032355860.1
• Coordinates: 29147..29353 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	29340..29401 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW57_RS23060	25050..25976	-	927	WP_097731803.1	tricarballylate utilization LysR family transcriptional regulator TcuR	-
JMW57_RS23065	26973..27830	-	858	WP_097731804.1	incFII family plasmid replication initiator RepA	-
JMW57_RS23070	27823..28305	-	483	WP_172949056.1	hypothetical protein	-
JMW57_RS23075	28298..28372	-	75	WP_001442103.1	RepA leader peptide Tap	-
JMW57_RS23080	28606..28863	-	258	WP_000083845.1	replication regulatory protein RepA	-
JMW57_RS23085	29147..29353	-	207	WP_032355860.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	29340..29401	+	62	NuclAT_1	-	Antitoxin
-	29340..29401	+	62	NuclAT_1	-	Antitoxin
-	29340..29401	+	62	NuclAT_1	-	Antitoxin
-	29340..29401	+	62	NuclAT_1	-	Antitoxin
JMW57_RS23090	29984..30196	-	213	WP_089574766.1	hypothetical protein	-
JMW57_RS23095	30329..30889	-	561	WP_097731806.1	fertility inhibition protein FinO	-
JMW57_RS23100	30944..31690	-	747	WP_201524626.1	conjugal transfer pilus acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..91228	91228

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (23-64)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7856.40 Da
• Isoelectric Point: 8.8807

>T291238 WP_032355860.1 NZ_LR890509:c29353-29147 [Escherichia coli]
MKYLNTTDCSLFFAERSKFMTKYALIGLLAVCAMVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 62 bp

>AT291238 NZ_LR890509:29340-29401 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin