Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 104150..104652 Replicon chromosome
Accession NZ_LR890508
Organism Escherichia coli isolate MSB1_9I-sc-2280417

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JMW57_RS00515 Protein ID WP_000767829.1
Coordinates 104398..104652 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMW57_RS00510 Protein ID WP_001259255.1
Coordinates 104150..104401 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW57_RS00485 99328..100395 - 1068 WP_201524524.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JMW57_RS00490 100395..101465 - 1071 WP_201524525.1 histidinol-phosphate transaminase -
JMW57_RS00495 101462..102766 - 1305 WP_201524526.1 histidinol dehydrogenase -
JMW57_RS00500 102772..103671 - 900 WP_201524527.1 ATP phosphoribosyltransferase -
JMW57_RS00505 103817..103867 - 51 WP_001364200.1 his operon leader peptide -
JMW57_RS00510 104150..104401 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMW57_RS00515 104398..104652 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMW57_RS00520 104735..105559 + 825 WP_000754737.1 SDR family oxidoreductase -
JMW57_RS00525 105605..106534 + 930 WP_000803351.1 LysR family transcriptional regulator -
JMW57_RS00530 106749..106811 + 63 WP_010723108.1 membrane protein YoeI -
JMW57_RS00535 106801..108159 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JMW57_RS00540 108338..109396 + 1059 WP_000492324.1 transport protein YeeE -
JMW57_RS00545 109410..109637 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T291219 WP_000767829.1 NZ_LR890508:104398-104652 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT291219 WP_001259255.1 NZ_LR890508:104150-104401 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References