Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 717608..718383 Replicon chromosome
Accession NZ_LR890490
Organism Klebsiella pneumoniae isolate INF341-sc-2280155

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1W1JAQ8
Locus tag JMX00_RS03555 Protein ID WP_009308645.1
Coordinates 717898..718383 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMX00_RS03550 Protein ID WP_004150912.1
Coordinates 717608..717901 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX00_RS03530 712816..713418 - 603 WP_004174410.1 short chain dehydrogenase -
JMX00_RS03535 713516..714427 + 912 WP_023288001.1 LysR family transcriptional regulator -
JMX00_RS03540 714428..715576 - 1149 WP_032103124.1 PLP-dependent aspartate aminotransferase family protein -
JMX00_RS03545 715587..716963 - 1377 WP_074187679.1 pyridoxal-phosphate dependent enzyme -
JMX00_RS03550 717608..717901 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMX00_RS03555 717898..718383 + 486 WP_009308645.1 GNAT family N-acetyltransferase Toxin
JMX00_RS03560 719087..719680 + 594 WP_004188553.1 hypothetical protein -
JMX00_RS03565 719777..719993 + 217 Protein_700 transposase -
JMX00_RS03575 720671..721384 - 714 WP_117079088.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 719777..719929 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17595.60 Da        Isoelectric Point: 8.5144

>T291172 WP_009308645.1 NZ_LR890490:717898-718383 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291172 WP_004150912.1 NZ_LR890490:717608-717901 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W1JAQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References