Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 715227..716002 Replicon chromosome
Accession NZ_LR890471
Organism Klebsiella pneumoniae isolate INF168-sc-2280023

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag JMX14_RS03535 Protein ID WP_004889762.1
Coordinates 715517..716002 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMX14_RS03530 Protein ID WP_004150912.1
Coordinates 715227..715520 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX14_RS03510 710436..711038 - 603 WP_004174410.1 short chain dehydrogenase -
JMX14_RS03515 711136..712047 + 912 WP_201519914.1 LysR family transcriptional regulator -
JMX14_RS03520 712048..713196 - 1149 WP_004889759.1 PLP-dependent aspartate aminotransferase family protein -
JMX14_RS03525 713207..714583 - 1377 WP_201519915.1 cystathionine beta-synthase -
JMX14_RS03530 715227..715520 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMX14_RS03535 715517..716002 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
JMX14_RS03540 716706..717298 + 593 Protein_696 hypothetical protein -
JMX14_RS03545 717395..717611 + 217 Protein_697 transposase -
JMX14_RS03550 718248..719090 + 843 WP_134912316.1 hypothetical protein -
JMX14_RS03555 719266..719484 + 219 WP_134912317.1 AlpA family transcriptional regulator -
JMX14_RS03560 719624..719941 + 318 WP_061351357.1 hypothetical protein -
JMX14_RS03565 720309..720605 + 297 WP_000032534.1 hypothetical protein -
JMX14_RS03570 720668..720904 + 237 WP_134912319.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 717395..717547 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T291123 WP_004889762.1 NZ_LR890471:715517-716002 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291123 WP_004150912.1 NZ_LR890471:715227-715520 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References