Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3960651..3961450 Replicon chromosome
Accession NZ_LR890466
Organism Escherichia coli isolate MSB1_7A-sc-2280394

Toxin (Protein)


Gene name yhaV Uniprot ID F0JQM9
Locus tag JMW16_RS18840 Protein ID WP_000347270.1
Coordinates 3960651..3961115 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0V9H1L4
Locus tag JMW16_RS18845 Protein ID WP_001551693.1
Coordinates 3961115..3961450 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW16_RS18810 3955652..3956086 - 435 WP_000948837.1 PTS sugar transporter subunit IIA -
JMW16_RS18815 3956104..3956982 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JMW16_RS18820 3956972..3957751 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JMW16_RS18825 3957762..3958235 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JMW16_RS18830 3958258..3959538 - 1281 WP_001551694.1 tagatose-bisphosphate aldolase subunit KbaZ -
JMW16_RS18835 3959787..3960596 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JMW16_RS18840 3960651..3961115 - 465 WP_000347270.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JMW16_RS18845 3961115..3961450 - 336 WP_001551693.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JMW16_RS18850 3961599..3963170 - 1572 WP_001273738.1 galactarate dehydratase -
JMW16_RS18855 3963545..3964879 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
JMW16_RS18860 3964895..3965665 + 771 WP_001551692.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17806.22 Da        Isoelectric Point: 9.6924

>T291105 WP_000347270.1 NZ_LR890466:c3961115-3960651 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12347.87 Da        Isoelectric Point: 4.6890

>AT291105 WP_001551693.1 NZ_LR890466:c3961450-3961115 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDTQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NQ90

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9H1L4

References