Detailed information of TA system TA029110

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1988302..1988609
• Replicon: chromosome
• Accession: NC_020537
• Organism: Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAI7S6_RS15625
• Protein ID: WP_011447039.1
• Coordinates: 1988433..1988609 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1988302..1988441 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAI7S6_RS09840	1983868..1984047	+	180	WP_000669791.1	hypothetical protein	-
SAI7S6_RS14830	1984358..1984618	+	261	WP_001791826.1	hypothetical protein	-
SAI7S6_RS09855	1984671..1985021	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAI7S6_RS09860	1985532..1985867	-	336	Protein_1855	SH3 domain-containing protein	-
SAI7S6_RS09865	1986518..1987009	-	492	WP_000920038.1	staphylokinase	-
SAI7S6_RS09870	1987200..1987955	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAI7S6_RS09875	1987967..1988221	-	255	WP_000611512.1	phage holin	-
SAI7S6_RS14835	1988273..1988380	+	108	WP_031762631.1	hypothetical protein	-
-	1988302..1988441	+	140	NuclAT_0	-	Antitoxin
-	1988302..1988441	+	140	NuclAT_0	-	Antitoxin
-	1988302..1988441	+	140	NuclAT_0	-	Antitoxin
-	1988302..1988441	+	140	NuclAT_0	-	Antitoxin
SAI7S6_RS15625	1988433..1988609	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAI7S6_RS09890	1988718..1989491	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAI7S6_RS09895	1989864..1990238	-	375	WP_000340977.1	hypothetical protein	-
SAI7S6_RS09900	1990294..1990581	-	288	WP_001262621.1	hypothetical protein	-
SAI7S6_RS14840	1990627..1990779	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / groEL	1984671..2024202	39531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29110 WP_011447039.1 NC_020537:c1988609-1988433 [Staphylococcus aureus subsp. aureus ST228]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29110 NC_020537:c1988609-1988433 [Staphylococcus aureus subsp. aureus ST228]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT29110 NC_020537:1988302-1988441 [Staphylococcus aureus subsp. aureus ST228]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin