Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 731859..732634 Replicon chromosome
Accession NZ_LR890464
Organism Klebsiella pneumoniae isolate INF079-sc-2280008

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag JMW83_RS03615 Protein ID WP_004889762.1
Coordinates 732149..732634 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMW83_RS03610 Protein ID WP_004150912.1
Coordinates 731859..732152 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW83_RS03590 727068..727670 - 603 WP_002916735.1 short chain dehydrogenase -
JMW83_RS03595 727768..728679 + 912 WP_014906929.1 LysR family transcriptional regulator -
JMW83_RS03600 728680..729828 - 1149 WP_014906930.1 PLP-dependent aspartate aminotransferase family protein -
JMW83_RS03605 729839..731215 - 1377 WP_014906931.1 pyridoxal-phosphate dependent enzyme -
JMW83_RS03610 731859..732152 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMW83_RS03615 732149..732634 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
JMW83_RS03620 733338..733931 + 594 WP_117248817.1 hypothetical protein -
JMW83_RS03625 734028..734244 + 217 Protein_713 transposase -
JMW83_RS03635 734922..735635 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 734028..734180 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T291073 WP_004889762.1 NZ_LR890464:732149-732634 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291073 WP_004150912.1 NZ_LR890464:731859-732152 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References