Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 776737..777512 Replicon chromosome
Accession NZ_LR890457
Organism Klebsiella pneumoniae isolate KSB1_6G-sc-2280276

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag JMX47_RS03910 Protein ID WP_004150910.1
Coordinates 777027..777512 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMX47_RS03905 Protein ID WP_004150912.1
Coordinates 776737..777030 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX47_RS03885 771945..772547 - 603 WP_002916735.1 short chain dehydrogenase -
JMX47_RS03890 772645..773556 + 912 WP_004188550.1 LysR family transcriptional regulator -
JMX47_RS03895 773557..774705 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
JMX47_RS03900 774716..776092 - 1377 WP_004217775.1 cystathionine beta-synthase -
JMX47_RS03905 776737..777030 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMX47_RS03910 777027..777512 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
JMX47_RS03915 778216..778809 + 594 WP_004188553.1 hypothetical protein -
JMX47_RS03920 778906..779122 + 217 Protein_771 transposase -
JMX47_RS03925 779566..780438 + 873 WP_004188557.1 ParA family protein -
JMX47_RS03930 780438..780821 + 384 WP_004150906.1 hypothetical protein -
JMX47_RS03935 780814..782181 + 1368 WP_004150905.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 778906..779058 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T291053 WP_004150910.1 NZ_LR890457:777027-777512 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT291053 WP_004150912.1 NZ_LR890457:776737-777030 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References