Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 362719..363365 Replicon chromosome
Accession NZ_LR890456
Organism Klebsiella pneumoniae isolate INF032-sc-2279918

Toxin (Protein)


Gene name higB Uniprot ID A0A6G4MDN2
Locus tag JMV68_RS01690 Protein ID WP_064148407.1
Coordinates 362719..363045 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMV68_RS01695 Protein ID WP_064148406.1
Coordinates 363066..363365 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV68_RS01680 358645..360078 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMV68_RS01685 360096..362543 + 2448 WP_002920561.1 glycogen phosphorylase -
JMV68_RS01690 362719..363045 + 327 WP_064148407.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMV68_RS01695 363066..363365 + 300 WP_064148406.1 helix-turn-helix transcriptional regulator Antitoxin
JMV68_RS01700 363428..364936 - 1509 WP_064148405.1 glycerol-3-phosphate dehydrogenase -
JMV68_RS01705 365141..365470 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMV68_RS01710 365521..366351 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
JMV68_RS01715 366401..367159 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12625.53 Da        Isoelectric Point: 5.1769

>T291038 WP_064148407.1 NZ_LR890456:362719-363045 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFS

Download         Length: 327 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10809.60 Da        Isoelectric Point: 10.1465

>AT291038 WP_064148406.1 NZ_LR890456:363066-363365 [Klebsiella pneumoniae]
MATLKELMAKHSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G4MDN2

Antitoxin

Source ID Structure

References