Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2875733..2876335 Replicon chromosome
Accession NZ_LR890410
Organism Escherichia coli isolate MSB2_1A-sc-2280429

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag JMW04_RS13660 Protein ID WP_000897302.1
Coordinates 2875733..2876044 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JMW04_RS13665 Protein ID WP_000356397.1
Coordinates 2876045..2876335 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW04_RS13630 2870763..2871548 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
JMW04_RS13635 2871647..2872246 + 600 WP_001314324.1 glucose-1-phosphatase -
JMW04_RS13640 2872240..2873112 + 873 WP_000920762.1 virulence factor BrkB family protein -
JMW04_RS13645 2873109..2873546 + 438 WP_000560978.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMW04_RS13650 2873591..2874532 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
JMW04_RS13655 2874596..2875504 - 909 WP_001774092.1 alpha/beta hydrolase -
JMW04_RS13660 2875733..2876044 + 312 WP_000897302.1 hypothetical protein Toxin
JMW04_RS13665 2876045..2876335 + 291 WP_000356397.1 helix-turn-helix domain-containing protein Antitoxin
JMW04_RS13670 2876694..2876972 + 279 WP_001296612.1 hypothetical protein -
JMW04_RS13675 2877368..2877586 + 219 WP_001314326.1 ribbon-helix-helix domain-containing protein -
JMW04_RS13680 2877802..2878731 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
JMW04_RS13685 2878728..2879363 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
JMW04_RS13690 2879360..2880262 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T290921 WP_000897302.1 NZ_LR890410:2875733-2876044 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT290921 WP_000356397.1 NZ_LR890410:2876045-2876335 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References