Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1928350..1929043 Replicon chromosome
Accession NZ_LR890410
Organism Escherichia coli isolate MSB2_1A-sc-2280429

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JMW04_RS09140 Protein ID WP_000415584.1
Coordinates 1928747..1929043 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JMW04_RS09135 Protein ID WP_000650107.1
Coordinates 1928350..1928745 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW04_RS09125 1924214..1926472 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
JMW04_RS09130 1926610..1928217 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JMW04_RS09135 1928350..1928745 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JMW04_RS09140 1928747..1929043 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JMW04_RS09145 1929248..1929730 - 483 WP_000183505.1 transcriptional regulator -
JMW04_RS09150 1929783..1930175 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JMW04_RS09155 1930327..1930986 + 660 WP_001221493.1 two-component system response regulator QseB -
JMW04_RS09160 1930983..1932332 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
JMW04_RS09165 1932378..1932710 - 333 WP_000917685.1 DUF2645 family protein -
JMW04_RS09170 1933029..1933610 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JMW04_RS09175 1933641..1933955 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1919887..1929043 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T290918 WP_000415584.1 NZ_LR890410:c1929043-1928747 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT290918 WP_000650107.1 NZ_LR890410:c1928745-1928350 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References