290914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 780756..781258 Replicon chromosome
Accession NZ_LR890410
Organism Escherichia coli isolate MSB2_1A-sc-2280429

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag JMW04_RS03900 Protein ID WP_000767822.1
Coordinates 780756..781010 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JMW04_RS03905 Protein ID WP_001259255.1
Coordinates 781007..781258 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW04_RS03880 777249..778607 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
JMW04_RS03885 778597..778659 - 63 WP_010723108.1 membrane protein YoeI -
JMW04_RS03890 778874..779803 - 930 WP_000803366.1 LysR family transcriptional regulator -
JMW04_RS03895 779849..780673 - 825 WP_000754737.1 SDR family oxidoreductase -
JMW04_RS03900 780756..781010 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JMW04_RS03905 781007..781258 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JMW04_RS03910 781541..781591 + 51 WP_001364200.1 his operon leader peptide -
JMW04_RS03915 781737..782636 + 900 WP_000131779.1 ATP phosphoribosyltransferase -
JMW04_RS03920 782642..783946 + 1305 WP_001445483.1 histidinol dehydrogenase -
JMW04_RS03925 783943..785013 + 1071 WP_001538918.1 histidinol-phosphate transaminase -
JMW04_RS03930 785013..786080 + 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T290914 WP_000767822.1 NZ_LR890410:c781010-780756 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT290914 WP_001259255.1 NZ_LR890410:c781258-781007 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References