Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3994732..3995382 Replicon chromosome
Accession NZ_LR890405
Organism Escherichia coli isolate MSB1_7C-sc-2280317

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JMW09_RS19260 Protein ID WP_000263532.1
Coordinates 3995041..3995382 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID U9YXQ7
Locus tag JMW09_RS19255 Protein ID WP_000212552.1
Coordinates 3994732..3995031 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW09_RS19230 3990180..3990491 - 312 WP_000415004.1 hypothetical protein -
JMW09_RS19235 3990496..3990888 - 393 WP_000285322.1 flagellar export chaperone FliS -
JMW09_RS19240 3990911..3992227 - 1317 WP_000609678.1 flagellar filament capping protein FliD -
JMW09_RS19245 3992432..3993346 - 915 WP_000949083.1 lateral flagellin LafA -
JMW09_RS19250 3993832..3994674 + 843 WP_000022366.1 winged helix-turn-helix domain-containing protein -
JMW09_RS19255 3994732..3995031 - 300 WP_000212552.1 helix-turn-helix transcriptional regulator Antitoxin
JMW09_RS19260 3995041..3995382 - 342 WP_000263532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW09_RS19265 3995458..3996435 - 978 WP_001195938.1 hypothetical protein -
JMW09_RS19270 3996452..3997381 - 930 WP_001266799.1 flagellar hook-associated protein FlgL -
JMW09_RS19275 3997396..3998772 - 1377 WP_000367245.1 flagellar hook-associated protein FlgK -
JMW09_RS19280 3998948..3999247 - 300 WP_000867281.1 rod-binding protein -
JMW09_RS19285 3999247..4000347 - 1101 WP_001181876.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13031.86 Da        Isoelectric Point: 6.4677

>T290898 WP_000263532.1 NZ_LR890405:c3995382-3995041 [Escherichia coli]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRKHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11004.86 Da        Isoelectric Point: 9.7665

>AT290898 WP_000212552.1 NZ_LR890405:c3995031-3994732 [Escherichia coli]
MATLKELMAKQSPESQVRIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRIAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U9YXQ7

References