Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 349018..349664 Replicon chromosome
Accession NZ_LR890391
Organism Klebsiella pneumoniae isolate KSB2_2C-sc-2280354

Toxin (Protein)


Gene name higB Uniprot ID A0A332YAY3
Locus tag JMW68_RS01600 Protein ID WP_032435150.1
Coordinates 349018..349365 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag JMW68_RS01605 Protein ID WP_002920557.1
Coordinates 349365..349664 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW68_RS01590 344944..346377 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMW68_RS01595 346395..348842 + 2448 WP_002920561.1 glycogen phosphorylase -
JMW68_RS01600 349018..349365 + 348 WP_032435150.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW68_RS01605 349365..349664 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
JMW68_RS01610 349727..351235 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
JMW68_RS01615 351440..351769 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMW68_RS01620 351820..352650 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
JMW68_RS01625 352700..353458 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13531.52 Da        Isoelectric Point: 5.6749

>T290851 WP_032435150.1 NZ_LR890391:349018-349365 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT290851 WP_002920557.1 NZ_LR890391:349365-349664 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332YAY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References