Detailed information of TA system TA029080

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1988482..1988789
• Replicon: chromosome
• Accession: NC_020533
• Organism: Staphylococcus aureus subsp. aureus ST228

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAI4T8_RS14590
• Protein ID: WP_011447039.1
• Coordinates: 1988613..1988789 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1988482..1988621 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAI4T8_RS09845	1984048..1984227	+	180	WP_000669791.1	hypothetical protein	-
SAI4T8_RS09855	1984538..1984798	+	261	WP_001791826.1	hypothetical protein	-
SAI4T8_RS09860	1984851..1985201	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAI4T8_RS09865	1985712..1986047	-	336	Protein_1854	SH3 domain-containing protein	-
SAI4T8_RS09870	1986698..1987189	-	492	WP_000920038.1	staphylokinase	-
SAI4T8_RS09875	1987380..1988135	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAI4T8_RS09880	1988147..1988401	-	255	WP_000611512.1	phage holin	-
SAI4T8_RS09885	1988453..1988560	+	108	WP_031762631.1	hypothetical protein	-
-	1988482..1988621	+	140	NuclAT_0	-	Antitoxin
-	1988482..1988621	+	140	NuclAT_0	-	Antitoxin
-	1988482..1988621	+	140	NuclAT_0	-	Antitoxin
-	1988482..1988621	+	140	NuclAT_0	-	Antitoxin
SAI4T8_RS14590	1988613..1988789	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAI4T8_RS09895	1988898..1989671	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAI4T8_RS09900	1990044..1990418	-	375	WP_000340977.1	hypothetical protein	-
SAI4T8_RS09905	1990474..1990761	-	288	WP_001262621.1	hypothetical protein	-
SAI4T8_RS09910	1990807..1990959	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / groEL	1984851..2024766	39915

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29080 WP_011447039.1 NC_020533:c1988789-1988613 [Staphylococcus aureus subsp. aureus ST228]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29080 NC_020533:c1988789-1988613 [Staphylococcus aureus subsp. aureus ST228]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT29080 NC_020533:1988482-1988621 [Staphylococcus aureus subsp. aureus ST228]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin