Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 722845..723620 Replicon chromosome
Accession NZ_LR890369
Organism Klebsiella pneumoniae isolate INF354-sc-2280183

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag JMW41_RS03575 Protein ID WP_021314147.1
Coordinates 723135..723620 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMW41_RS03570 Protein ID WP_004150912.1
Coordinates 722845..723138 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW41_RS03550 718053..718655 - 603 WP_021440720.1 short chain dehydrogenase -
JMW41_RS03555 718753..719664 + 912 WP_004188550.1 LysR family transcriptional regulator -
JMW41_RS03560 719665..720813 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
JMW41_RS03565 720824..722200 - 1377 WP_074194669.1 cystathionine beta-synthase -
JMW41_RS03570 722845..723138 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMW41_RS03575 723135..723620 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
JMW41_RS03580 724324..724917 + 594 WP_004188553.1 hypothetical protein -
JMW41_RS03585 725014..725230 + 217 Protein_702 transposase -
JMW41_RS03590 726005..726889 + 885 WP_013095145.1 ParA family protein -
JMW41_RS03595 726882..728246 + 1365 WP_044158999.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 725014..725166 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T290784 WP_021314147.1 NZ_LR890369:723135-723620 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT290784 WP_004150912.1 NZ_LR890369:722845-723138 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References