Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 365293..365939 Replicon chromosome
Accession NZ_LR890369
Organism Klebsiella pneumoniae isolate INF354-sc-2280183

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag JMW41_RS01690 Protein ID WP_016529833.1
Coordinates 365293..365640 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag JMW41_RS01695 Protein ID WP_004174017.1
Coordinates 365640..365939 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW41_RS01680 361219..362652 + 1434 WP_002920564.1 glycogen synthase GlgA -
JMW41_RS01685 362670..365117 + 2448 WP_002920561.1 glycogen phosphorylase -
JMW41_RS01690 365293..365640 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW41_RS01695 365640..365939 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
JMW41_RS01700 366002..367510 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
JMW41_RS01705 367715..368044 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
JMW41_RS01710 368095..368925 + 831 WP_032428425.1 rhomboid family intramembrane serine protease GlpG -
JMW41_RS01715 368975..369733 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T290783 WP_016529833.1 NZ_LR890369:365293-365640 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT290783 WP_004174017.1 NZ_LR890369:365640-365939 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References